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Insulin in the brain plays key role in feeding behaviour, new study finds

Diabetes UK - 21/06/2017
A new study has found that insulin in the brain helps regulate hunger and affects several important cognitive functions.

Researchers call for paradigm shift in treating type 2 diabetes

Diabetes UK - 21/06/2017
Existing type 2 diabetes medications that lower blood sugar levels can also reduce the risk of heart disease or stroke, researchers have found. The results from four different studies have shown that using certain medications that offer both glucose control and reduce the risk of heart problems. The review, led by Dr Faramarz Ismail-Beigi, Louis Stokes Cleveland VA Medical Center, looked at the effects of diabetes medications including Actos (pioglitazone), Jardiance (empagliflozin), Victoza (liraglutide), or semaglutide.

Poor sleep could raise HbA1c levels in teenagers with type 1 diabetes

Diabetes UK - 21/06/2017
Young people with type 1 diabetes who have poor sleeping habits could be at risk of increased HbA1c levels, a new study has suggested. The German study was developed so researchers could look at how broken sleep impacts glycemic control in teenagers with type 1 diabetes. Just over 190 young people aged around 16 years old were recruited into the trial, which used medical records to collect information on the participants.

First patient treated as Australian trial tests new antibody in type 1 diabetes

Diabetes UK - 21/06/2017
A Swiss pharmaceutical company has announced the first patient has been treated in its new type 1 diabetes trial. GeNeuro, based in Geneva, is testing its phase IIa study of GNbAC1, an antibody designed to target a protein that has been linked to various autoimmune diseases, including type 1 diabetes. This envelope protein (Env) is part of the human endogenous retrovirus (HERV) family, which researchers estimate to account for up to eight per cent of the human genome. "The objective of this Phase 2a study is to demonstrate GNbAC1's safety and potential benefit in preserving pancreatic function

Pioneering drug selection software helps find potential type 2 diabetes treatments

Diabetes UK - 20/06/2017
A major artificial intelligence biopharmaceutical company called twoXAR has demonstrated a new approach for selecting type 2 diabetes drugs which could be of huge future significance. The US firm successfully screened 25,000 potential drug candidates for a recent study looking at new type 2 diabetes treatments. The software swiftly selected three which showed to have the best efficacy and safety aspects. The platform uses twoXAR's artificial intelligence to analyse biological, chemical, and clinical data to predict and rank potentially relevant drugs.

Gut microbiome changes linked to numerous biomarkers of type 2 diabetes

Diabetes UK - 20/06/2017
A new study has identified links between alterations in gut microbial populations and multiple markers of obesity and type 2 diabetes. Changes to the gut microbiome and its associated genes are increasingly thought to be involved in obesity and type 2 diabetes through complex mechanisms that are not fully elucidated. Until now, scientists have focused on understanding the role of one gut microbial shift on one marker.

Positive findings in type 1 diabetes glucagon-blocking drug study

Diabetes UK - 20/06/2017
A single dose of a glucagon-blocking drug has been found to significantly improve blood sugar levels in people with type 1 diabetes, researchers say. REMD-477, which is a human antibody, can also substantially reduce the amount of insulin needed by those with type 1 diabetes. A team from the University of California, San Diego carried out a small study which involved 21 people with type 1 diabetes. Those who received the injection reached their target blood glucose levels more than those who were given the placebo.

High PCSK9 levels could affect blood sugar control in type 1 diabetes

Diabetes UK - 20/06/2017
Youngsters with type 1 diabetes have higher levels of PCSK9, which correlated with higher HbA1c levels, research suggests. These levels of PCSK9 were also shown to be higher in girls than boys, with or without type 1 diabetes. PCSK9 is an enzyme that activates other proteins, which previous studies have shown to be increased in people with type 2 diabetes.

High intensity exercise gives beta cells new strength, study finds

Diabetes UK - 19/06/2017
A small pilot study has found that six weeks of a high intensity training called CrossFit helped people with type 2 diabetes regain beta cell function and reduce their body fat. Researchers at the Case Western Reserve University had 12 adults with type 2 diabetes do 10 to 20 minutes of CrossFit at a gym three days per week for six weeks. Their workout consisted in completing several rounds of a wide variety of functional exercises, such as pull-ups, squats and push-ups, with each rep performed explosively. The participants were all considered sedentary prior to starting the program.

Finnish study examines links between type 1 diabetes and asthma

Diabetes UK - 19/06/2017
New light has been shed on the association between type 1 diabetes and asthma by an international study. The two conditions have been linked by previous studies but now research from Finland suggests having asthma increases the risk of type 1 diabetes by 41 per cent.

Type 2 diabetes prevention drive expanded by NHS England

Diabetes UK - 19/06/2017
A national campaign to help prevent people from developing type 2 diabetes has been extended. The NHS England initiative, which is targeting people at high risk of the condition, will be delivered at 13 new sites. Wave 2 of The Healthier You: NHS Diabetes Prevention Programme has just been announced and will reach a further 25 per cent of the country.

Hybrid-closed loop insulin system safe and effective for children with type 1 diabetes

Diabetes UK - 19/06/2017
A team of Stanford University researchers have shown a hybrid closed-loop insulin system can effectively control type 1 diabetes in children. The system, which is a near-artificial pancreas, was safe for both overall and overnight control and none of the children experienced any episodes of severe hypoglycemia. The findings were presented by Bruce A. Buckingham, MD at the 77th Scientific Sessions of the American Diabetes Association. Buckingham said: "There's a lot of work being done now on hybrid closed-loop systems.

NHS to announce further details on diabetes healthcare funding

Diabetes UK - 16/06/2017
Health teams across England will find out on Friday how £44m which has been set aside for diabetes care will be spent. According to The Diabetes Times, NHS England will also announce details about stage two of the national type 2 diabetes prevention drive, which was first introduced in 2016. Last year Clinical Commissioning Groups (CCGs) were invited to apply for a slice of the fund which was announced as part of the NHS's plan to improve health, care and improve efficiency.

Oral insulin trial fails to meet endpoint, but could help delay type 1 diabetes

Diabetes UK - 16/06/2017
Oral insulin has shown to be unsuccessful in preventing the development of type 1 diabetes in a new trial, but it did help delay the onset. The trial found that oral insulin led to some people experiencing a 31-month delay in the clinical development of type 1 diabetes, a finding hailed as "dramatic" by researchers. "Delaying type 1 diabetes is important," said lead author Carla J. Greenbaum, MD, of the Benaroya Research Institute in Seattle.

Researchers highlight focus on remission in treating diabetic foot ulcers

Diabetes UK - 16/06/2017
Doctors are being urged to pay closer attention to people's feet once they have recovered from an ulcer, a common diabetes complication. Some estimates indicate one third of people with diabetes will suffer from a foot ulcer at some point during their life, but the complication can be avoided if people maintain good blood sugar control and regularly check their feet for any signs of damage. Now, a research team from Arizona says diabetes healthcare teams should be turning their attentions to ulcer remission, rather than recovery. Lead author Dr David Armstong, professor of surgery and director

Low vitamin A linked to beta cell decline in mice

Diabetes UK - 15/06/2017
A new study has found that a lack of vitamin A may be linked to beta cell dysfunction and impaired insulin production in mice. The study, which appeared in the Endocrine Journal, shows that vitamin A binds to receptors, called GPRC5C, on the surface of beta cells. A team of researchers at the University of Lund, in Sweden, set out to find out why.

Untreated obstructive sleep apnea could worsen heart health and blood sugar levels

Diabetes UK - 15/06/2017
Proper treatment of obstructive sleep apnea (OSA) could have benefits for the heart and blood sugar levels, according to new research. People with OSA, a condition more likely to be experienced by people with type 2 diabetes, often suffer interrupted breathing as a result of airways becoming blocked during sleep.

Doctors told to adapt their language around diabetes patients

Diabetes UK - 15/06/2017
Doctors have been warned to watch the type of language they use around people with diabetes as it could impact their health.

Broccoli extract could help treat type 2 diabetes

Diabetes UK - 15/06/2017
A powder that contains broccoli extract has the potential to treat people with type 2 diabetes, a study has found. Scientists from the University of Gothenburg in Sweden report that a chemical found in broccoli sprouts, called sulphoraphane, reduced blood glucose levels in people with type 2 diabetes.

ADA identifies routes to improving mental health in people with diabetes

Diabetes UK - 14/06/2017
The American Diabetes Association (ADA) recently released a statement recognising that there is more to health than blood sugar management for people with diabetes. One important factor that tends to get short shrift is mental health and the social support needed to address emotional challenges that can compromise health outcomes. In its statement, the ADA is saying that healthcare providers need to put more time and energy focusing on these areas that often tend to be neglected.